446852-20-6Relevant academic research and scientific papers
Structure-based drug design, synthesis and screening of MmaA1 inhibitors as novel anti-TB agents
Veeravarapu, Hymavathi,Malkhed, Vasavi,Mustyala, Kiran Kumar,Vadija, Rajender,Malikanti, Ramesh,Vuruputuri, Uma,Muthyala, Murali Krishna Kumar
, p. 351 - 366 (2020/06/22)
Abstract: Tuberculosis is one of the leading causes of death across the world. The treatment regimens for tuberculosis are well established, but still the control of the disease faces many challenges such as lengthy treatment protocols, drug resistance an
Design, synthesis, antimycobacterial activity and molecular docking studies of novel 3- (N-substituted glycinamido) benzoic acid analogues as anti tubercular agents
Krishna Kumar Muthyala, Murali,Kurati, SonyPriya,Tirumalasetty, Mohan,Veeravarapu, Hymavathi,Wunnava, Umarani
supporting information, (2020/10/15)
We have recently identified mycolic acid methyl transferase (MmaA1) enzyme inhibitors as potential antitubercular agents using in silico modelling techniques. In continuation of that study, we synthesised a series of novel 3-(N-substituted glycinamido) benzoic acid derivatives with an aim to optimise the lead molecule. The newly synthesised compounds were evaluated for their in vitro antimycobacterial activity against M. tuberculosis H37Rv. Among these, 5 compounds A3, A4, A5, A6 and A10 exhibited most potent activity with an MIC value of 1.6 μg/ml. Further molecular docking studies were carried out to investigate the binding mode of the ligands with MmaA1 protein. The docking studies revealed that the ligands made strong interactions with the catalytic site residues TRP30, TYR 32, GLY 71, TRP 74, GLY 76, ALA 77 and GLU 136 of MmaA1 protein. Druglikeness and leadlikeness properties of the compounds were also studied using computational tools. The results of in silico and in vitro studies indicate that these novel compounds are propitious leads for tuberculosis therapy.
Synthesis of benzoic acids and polybenzamides containing tertiary alkylamino functionality
Khan, Gul Shahzada,Dickson, Benjamin D.,Barker, David
, p. 1790 - 1801 (2012/03/11)
The high-yielding and easily scalable synthesis of a number of benzoic acids bearing a tertiary alkylamino functionality has been achieved. The flexible synthesis began from readily available aminobenzoic acids or terephthaloyl chloride and requires almost no chromatography. Coupling of the synthesised amino acids to a range of substituted anilines was achieved when utilizing a specific combination of DIC, HOBt and DMAP.
