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2-Bromo-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine is a complex organic chemical compound that belongs to the class of pyridines and pyrazoles. These are heterocyclic aromatic organic compounds characterized by the presence of atoms other than carbon in a ring with alternating double and single bonds. 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE is significant in various chemical reactions and is often utilized in research and industrial applications. Its core structures are prevalent in medicinal chemistry, making it a potential candidate for pharmaceutical development. However, specific data such as toxicity, mode of action, or detailed physical and chemical properties may vary and require further study.

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  • 446880-81-5 Structure
  • Basic information

    1. Product Name: 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE
    2. Synonyms: 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE;2-bromo-4-(3-pyridin-2-yl-1H-pyrazol-yl)pyridine;2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine
    3. CAS NO:446880-81-5
    4. Molecular Formula: C13H9BrN4
    5. Molecular Weight: 301.14136
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 446880-81-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 457.4±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.550±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. PKA: 8.17±0.50(Predicted)
    10. CAS DataBase Reference: 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE(446880-81-5)
    12. EPA Substance Registry System: 2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE(446880-81-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 446880-81-5(Hazardous Substances Data)

446880-81-5 Usage

Uses

Used in Pharmaceutical Research:
2-Bromo-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
2-BROMO-4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)-PYRIDINE serves as a valuable building block in complex organic synthesis reactions. Its presence in the core structures of numerous medicinal chemistry applications makes it a versatile component in the creation of novel molecules with desired properties.
Used in Research and Development:
2-Bromo-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine is employed in research and development settings to explore its potential applications and properties. Its role in the synthesis of new compounds and its interaction with other molecules can provide insights into its possible uses in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 446880-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,6,8,8 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 446880-81:
(8*4)+(7*4)+(6*6)+(5*8)+(4*8)+(3*0)+(2*8)+(1*1)=185
185 % 10 = 5
So 446880-81-5 is a valid CAS Registry Number.

446880-81-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine

1.2 Other means of identification

Product number -
Other names 2-bromo-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:446880-81-5 SDS

446880-81-5Relevant articles and documents

Formulated and/or co-formulated liposome compositions containing TFGB antagonist prodrugs useful in the treatment of cancer and methods thereof

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, (2021/08/27)

Formulated and/or co-formulated liposomes (LNP) and solid-lipid nanoparticles (SLNP) comprising TB Prodrugs and methods of making the LNPs and SLNPs are disclosed herein. The TB prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit

ALK5 INHIBITOR CONJUGATES AND USES THEREOF

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, (2021/07/17)

The present disclosure relates to targeted drug conjugates comprising ALK5 inhibitors and targeting moieties that direct the ALK5 inhibitors to cells involved in fibrosis and cancer, for example myofibroblasts, activated fibroblasts and transitioning fibr

ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES

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Paragraph 0150; 0158-0160, (2020/02/06)

The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES

-

Paragraph 0166; 0174-0176, (2020/06/07)

The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

ANTIB0DY-ALK5 INHIBITOR CONJUGATES AND THEIR USES

-

Paragraph 0155; 0163-0165, (2021/01/21)

The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling

Ciayadi, Rudy,Potdar, Mahesh,Walton, Kelly L.,Harrison, Craig A.,Kelso, Geoffrey F.,Harris, Simon J.,Hearn, Milton T.W.

, p. 5642 - 5645 (2011/10/09)

Novel inhibitors of TGF-β1 and activin A signalling based on a 2-aryl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine pharmacophore have been synthesised. Compounds containing phenyl or aromatic nitrogen heterocycle substituents inhibited both types of signalling with HEK-293T cells in culture, with a selectivity preference for TGF-β1. Synthetic compounds containing pyridin-3-yl, pyrazol-4-yl, pyrazol-1-yl or 1H-imidazoyl-1-yl substituents exhibited structural and functional attributes suitable for further investigation related to the development of more potent TGF-β inhibitors.

Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N- (tetrahydro-2H-pyran-4-yl)benzamide (GW788388): A potent, selective, and orally active transforming growth factor-β type I receptor inhibitor

Gellibert, Fran?oise,De Gouville, Anne-Charlotte,Woolven, James,Mathews, Neil,Nguyen, Van-Loc,Bertho-Ruault, Cécile,Patikis, Angela,Grygielko, Eugene T.,Laping, Nicholas J.,Huet, Stéphane

, p. 2210 - 2221 (2007/10/03)

Inhibitors of transforming growth factor β (TGF-β) type I receptor (ALK5) offer a novel approach for the treatment of fibrotic diseases such as renal, hepatic, and pulmonary fibrosis. The optimization of a novel phenylpyridine pyrazole series (1a) led to the identification of potent, selective, and orally active ALK5 inhibitors. The cellular potency and pharmacokinetics profiles of these derivatives were improved and several compounds presented antifibrotic activity when orally administered to rats in an acute liver model of dimethylnitrosamine- (DMN-) induced expression of collagen IA1 mRNA, a major gene contributing to excessive extra cellular matrix deposit. One of the most potent ALK5 inhibitors identified in this chemical series, compound 13d (GW788388), reduced the expression of collagen IA1 by 80% at a dose of 1 mg/kg twice a day (b.i.d.). This compound significantly reduced the expression of collagen IA1 mRNA when administered orally at 10 mg/kg once a day (u.i.d.) in a model of puromycin aminonucleoside-induced renal fibrosis.

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