447420-69-1

Basic information

• Product Name: di-tert-butyl 2-({[(benzyloxy)carbonyl]amino}methyl)malonate
• Synonyms: di-tert-butyl 2-({[(benzyloxy)carbonyl]amino}methyl)malonate
• CAS NO: 447420-69-1
• Molecular Weight: 379.453
• Mol File: 447420-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-tert-butyl 2-({[(benzyloxy)carbonyl]amino}methyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl 2-({[(benzyloxy)carbonyl]amino}methyl)malonate(447420-69-1)
• EPA Substance Registry System: di-tert-butyl 2-({[(benzyloxy)carbonyl]amino}methyl)malonate(447420-69-1)

Safety Data

• Hazardous Substances Data: 447420-69-1(Hazardous Substances Data)

Upstream product

• 621-84-1 O-benzyl carbamate 
• 541-16-2 t-butyl malonate 
• 125453-11-4 benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate 

Downstream Products

• 815611-04-2 C₁₂H₁₇NO₄ 

Relevant articles and documents

Convenient preparation of tert-butyl β-(protected amino)esters

Refluxing an aldehyde 1 with benzotriazole and benzylcarbamate in the presence of a catalytic amount of p-TsOH gave the corresponding benzyloxycarbonylamino-1-(1-benzotriazolyl)alkane 2 in good yields. Compounds 2 treated with substituted tert-butyl acetates 3 using LDA as a base afford smoothly and under mild conditions the N-2-protected 3-aminoalkanoic esters 4.