447462-74-0

Basic information

• Product Name: (3S,8aR)-3-methyl-1-(4-methylphenyl)hexahydroimidazo[1,2-a]pyridin-2(3H)-one
• Synonyms: (3S,8aR)-3-methyl-1-(4-methylphenyl)hexahydroimidazo[1,2-a]pyridin-2(3H)-one
• CAS NO: 447462-74-0
• Molecular Weight: 244.337
• Mol File: 447462-74-0.mol

Chemical Properties

• CAS DataBase Reference: (3S,8aR)-3-methyl-1-(4-methylphenyl)hexahydroimidazo[1,2-a]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,8aR)-3-methyl-1-(4-methylphenyl)hexahydroimidazo[1,2-a]pyridin-2(3H)-one(447462-74-0)
• EPA Substance Registry System: (3S,8aR)-3-methyl-1-(4-methylphenyl)hexahydroimidazo[1,2-a]pyridin-2(3H)-one(447462-74-0)

Safety Data

• Hazardous Substances Data: 447462-74-0(Hazardous Substances Data)

Upstream product

• 372187-66-1 tert-butyl N-[(1S)-1-methyl-2-oxo-2-(4-toluidino)ethyl]carbamate 
• 106-49-0 p-toluidine 
• 111-30-8 Glutaraldehyde 
• 160981-43-1 (2S)-2-amino-N-(4-methylphenyl)propanamide 

Relevant articles and documents

Syntheses of optically active tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones and hexahydroimidazo[1,2-a]pyridin-2(3H)-ones

The reactions of (2S)-2-amino-2-substituted-N-(4-nitrophenyl)acetamides 16a-c, succindialdehyde (13), and benzotriazole afforded enantiopure (3S,5R,7aR)-5-(1H-1,2,3-benzotriazol-1-yl)-3-substituted-1-(4-nitrophenyl) tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones 17a-c, which were converted by sodium borohydride into (3S,7aR)-3-substituted-1-(4-nitrophenyl)tetrahydro-1H-pyrrolo[1, 2-a]imidazol-2-ones 18a-c. Chiral (2S)-2-amino-2-substituted-N-(4-methylphenyl)acetamides 12a-d, easily prepared in two steps from N-Boc-α-amino acids 10a-d, similarly reacted with glutaraldehyde (20) and benzotriazole to generate 5-benzotriazolyl-3-substituted-hexahydroimidazo[1,2-a]pyridin 2(3H)-ones 21a-d, which were converted by sodium borohydride directly into optically active 3-substituted-hexahydroimidazo[1,2-a]pyridin-2(3H)-ones 22a-d.