4480-82-4Relevant academic research and scientific papers
Ninhydrin reaction with phenylethylamine: unavoidable by-products
Gonzalez-O?ate, Andrés,Quevedo, Rodolfo
, (2020)
Abstract: Ninhydrin and phenylethylamine reacted to form a complex mixture from which four products were isolated: a benzo-fused spiroheterocyclic and a pyrrole product resulting from tricomponent condensation between ninhydrin, phenylethylamine and phenylacetaldehyde produced in situ, a 2-amino-1,3-indandione dimerisation-dehydrogenation product and a Schiff base. This article analyses these compounds’ structure and proposes reaction mechanisms contributing to knowledge regarding ninhydrin and phenylethylamine chemical reactivity. Graphic abstract: Ninhydrin and phenylethylamine reacted to form a benzo-fused spiroheterocyclic, a pyrrole, a 2-amino-1,3-indandione dimerisation-dehydrogenation product and a Schiff base.[Figure not available: see fulltext.].
