4481-48-5Relevant academic research and scientific papers
Antimicrobial and antiproliferative activities of novel synthesized 6-(quinolin-2-ylthio) pyridine derivatives with molecular docking study as multi-targeted JAK2/STAT3 inhibitors
Nafie, Mohamed S.,Mahgoub, Sebaey,Amer, Atef M.
, p. 553 - 564 (2020/10/02)
Quinoline derivatives are attracting considerable interest due to their biological importance. In this paper, several 2-amino-4-aryl-6-(quinolin-2-ylthio)pyridine-3,5-dicarbonitrile derivatives are synthesized by adopting a one-pot reaction of quinoline-2-thione, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide in absolute ethanol. The structures of these newly synthesized compounds were determined using different spectroscopic techniques, including elemental analyses, IR, 1H NMR, and MS. The synthesized derivatives were screened for their antimicrobial and cytotoxic activities. Compounds 4a, 4b, 4d, and 4e exhibited promising antimicrobial activity compared to antibacterial and antifungal standard drugs. Additionally, 4f, 4d, and 4g showed potent cytotoxic activity against both MCF-7 and A549 cells with IC50 values (6.39–9.3?μM). Our molecular docking results of compound 4f prove good binding affinity toward the three tested proteins as Jak2/STATA3 inhibition and are in accordance with the RT-PCR mRNA expressions of the compound against MCF-7 cells which downregulated the Jak2 and STAT3 genes, and this may be the proposed mode of action for anti-breast cancer activity.
REAKTIONEN VON THIOXOHETEROCYCLEN MIT N-CHLORAMIDEN III. 2- ODER 4-THIOPYRIDONE OHNE SUBSTITUENTEN AM STICKSTOFF UND NATRIUM-N-CHLORBENZOLSULFONAMIDE
Boberg, Friedrich,Bruchmann, Bernd,Garming, Alfons,Nink, Gunter
, p. 313 - 326 (2007/10/02)
2- and 4-pyridinethiones (A) react with sodium N-chlorobenzenesulfonamides (1) in alcoholic solvents to N-(pyridylthio)benzenesulfonamides (C), sodium N,N'-bis(phenylsulfonyl)-S-pyridylsulfodiimidates (D) and S-alkoxy-N-phenylsulfonyl-S-pyridylsulfimides (E).Constitution proofs for the new compounds D, E are reactions and 1H-, 13C-, 15N-nmr data.
INTRODUCTION OF SULFUR IN COMPOUNDS WITH REACTIVE HALOGEN ATOMS VIA THE t-BUTYLTHIOLATE ANION
Becher, Jan,Lundsgaard, John
, p. 131 - 138 (2007/10/02)
The preparation of t-butylthioethers from examples of halogen substituted heterocycles are described.S-Dealkylation of the t-butylthioethers readily takes place by pyrolyses with catalytic amounts of aluminum chloride or p-toluenesulfonic acid.
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS XXXII Reactions of 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide with compounds containing the N=O function
Jorgensen, K. A.,Shabana, R.,Scheibye, S.,Lawesson, S.-O.
, p. 247 - 254 (2007/10/02)
Reactions of 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide, 1, with a series of substrates having a semipolar bond have been studied.C-Nitroso compounds react to give azoxy compounds or azo compounds, whereas N,N-dimethyl-p-nitrosoaniline furnishes p-dimethylamino-N-thiosulfinyl-aniline, 6, and benzofurazan-1-oxide produces 2,1,3-benzothiadiazole.N-nitroso compounds react with 1 to give phosphorous heterocycles in which the N-nitroso function is destroyed.Elimination of HNO from certain N-nitroso compounds has also been observed.Nitrones and N-oxides react with 1 to form the corresponding deoxygenated products.In the case of quinoline-N-oxide, small amounts of quinoline-2-thione could be isolated in addition to the deoxygenated product.Mechanistic considerations are presented.
