N-Desethyl Vardenafil is a metabolite of Vardenafil, a phosphodiesterase 5 (PDE5) inhibitor, which is formed by the action of cytochrome P450 (CYP) 3A4 and CYP3A5 enzymes. It is a white to off-white solid and plays a significant role in the therapeutic effects of Vardenafil.
448184-46-1
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Basic information
- Product Name: N-Desethyl Vardenafil
- Synonyms: 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-piperazine;2-(2-ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
- CAS NO:448184-46-1
- Molecular Formula: C21H28N6O4S
- Molecular Weight: 460.556
- EINECS: N/A
- Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 448184-46-1.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 699.8±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.44g/cm3
- Refractive Index: 1.683
- Storage Temp.: -20°C Freezer, Under Inert Atmosphere
- Solubility: N/A
- PKA: 7.73±0.10(Predicted)
- CAS DataBase Reference: N-Desethyl Vardenafil(CAS DataBase Reference)
- NIST Chemistry Reference: N-Desethyl Vardenafil(448184-46-1)
- EPA Substance Registry System: N-Desethyl Vardenafil(448184-46-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 448184-46-1(Hazardous Substances Data)
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448184-46-1 Usage
Uses
Used in Pharmaceutical Industry:N-Desethyl Vardenafil is used as an active metabolite for enhancing the efficacy of Vardenafil, a PDE5 inhibitor. It contributes to the treatment of erectile dysfunction by increasing blood flow to the penis, thus aiding in achieving and maintaining an erection.
Used in Research and Development:
N-Desethyl Vardenafil is used as a research compound for studying the pharmacological properties and mechanisms of PDE5 inhibitors. This helps in the development of new drugs and therapies for various conditions, including erectile dysfunction and other related disorders.
Used in Quality Control and Standardization:
N-Desethyl Vardenafil is used as a reference material for quality control and standardization of Vardenafil-containing products. It ensures the consistency, potency, and safety of these medications by providing a benchmark for comparison and analysis.
Check Digit Verification of cas no
The CAS Registry Mumber 448184-46-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,1,8 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.Calculate Digit Verification of CAS Registry Number 448184-46:
(8*4)+(7*4)+(6*8)+(5*1)+(4*8)+(3*4)+(2*4)+(1*6)=171
171 % 10 = 1
So 448184-46-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H28N6O4S/c1-4-6-18-23-14(3)19-21(28)24-20(25-27(18)19)16-13-15(7-8-17(16)31-5-2)32(29,30)26-11-9-22-10-12-26/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,24,25,28)
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N-Desethyl Vardenafil
