448195-99-1

Basic information

• Product Name: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(4-methylphenyl)-
• CAS NO: 448195-99-1
• Molecular Formula: C17H21NO2S
• Molecular Weight: 303.425
• Mol File: 448195-99-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(4-methylphenyl)-(448195-99-1)
• EPA Substance Registry System: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(4-methylphenyl)-(448195-99-1)

Safety Data

• Hazardous Substances Data: 448195-99-1(Hazardous Substances Data)

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 106-49-0 p-toluidine 

Downstream Products

• 680588-87-8 2-[(4-tert-butyl-benzenesulfonyl)-p-tolyl-amino]-N,N-diethyl-acetamide 

Relevant articles and documents

Sulfonamide compound and metal-free catalytic construction method and application thereof

The invention discloses a sulfonamide compound as shown in a formula (I) which is described in the specification and a synthesis method thereof. A series of sulfonamide compounds are obtained throughreaction of nitroaromatic hydrocarbon, an inorganic sulfur reagent and boric acid as reaction raw materials in a solvent under the action of alkali and an additive. Metal catalysis and an additional reducing agent are not needed, an inorganic sulfur reagent is used as a sulfur source and a reducing agent, and a series of sulfonamide compounds are constructed in one step by a three-component one-pot method. The invention also discloses an application of the sulfonamide compound in synthesis of sulfonamide drugs. The raw materials of the synthesis method are wide in source, cheap and easy to obtain; the reaction operation is simple; the substrate universality is high; and the synthesis method is economic and practical. The sulfonamide compound has high practical value and a wide applicationprospect.

Copper-catalyzed redox coupling of nitroarenes with sodium sulfinates

A simple copper-catalyzed redox coupling of sodium sulfinates and nitroarenes is described. In this process, abundant and stable nitroarenes serve as both the nitrogen sources and oxidants, and sodium sulfinates act as both reactants and reductants. A variety of aromatic sulfonamides were obtained in moderate to good yields with broad substrate scope. No external additive is employed for this kind of transformation.

SULFONYLAMINO-ACETIC ACID DERIVATIVES

The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.