448917-47-3

Upstream product

• 15307-86-5 [2-(2,6-dichloroanilino)phenyl]acetic acid 
• 141-43-5 ethanolamine 
• 15307-77-4 ethyl 2-[2-(2,6-dichlorophenylamino)phenyl]acetate 

Downstream Products

• 1043448-26-5 C₁₆H₁₄Cl₂N₄O₆ 

Relevant academic research and scientific papers

Synthesis of furoxan derivatives of diclofenac as potent anti-inflammatory agents with reduced GI toxicity

A new series of NO donating furoxan derivatives of diclofenac have been synthesized by linking diclofenac to selected furoxan moieties and have been investigated for their anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, hepatotoxicity, histopathological and NO releasing properties. All the hybrid derivatives are endowed 'with antiinflammatory activity comparable to diclofenac but unlike this drug they show reduced GI toxicity. The compounds 4-[(2-(2-(2-(2,6-dichlorophenylamino)phenyl)acetamido)ethoxy)carbonyl]-3-methyl furoxan 12 having amide-ester linkage and 4-[(2-(2-(2,6-dichlorophenylamino)phenyl)acetoxy)methyl]-3-methyl-furoxan 13a having ester linkage show greater anti-inflammatory activity comparable to standard drug diclofenac. These compounds 12 and 13a also show higher gastrointestinal protection in comparison to standard drug diclofenac.

N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF

ABSTRACT Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux thr