448924-75-2

Basic information

• Product Name: C₂₃H₂₈BrNO₄S₂
• Synonyms: C₂₃H₂₈BrNO₄S₂
• CAS NO: 448924-75-2
• Molecular Weight: 526.516
• Mol File: 448924-75-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₈BrNO₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₈BrNO₄S₂(448924-75-2)
• EPA Substance Registry System: C₂₃H₂₈BrNO₄S₂(448924-75-2)

Safety Data

• Hazardous Substances Data: 448924-75-2(Hazardous Substances Data)

Upstream product

• 13610-11-2 [4'-Bromo-(1,1'-biphenyl)-4-yl]-sulfonyl chloride 

Relevant articles and documents

Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors

Inhibitors of MMP enzymes are cyclic sulfonamides of Formula I or a pharmaceutically acceptable salt thereof, and cyclic sulfonamides of Formula III or a pharmaceutically acceptable salt thereof, wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH. The compounds of Formulas I and III are useful for the treatment of diseases mediated by an MMP enzyme, including cancer, osteoarthritis, rheumatoid arthritis, heart failure, and inflammation.