448949-22-2

Basic information

• Product Name: 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid
• Synonyms: 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid
• CAS NO: 448949-22-2
• Molecular Weight: 420.425
• Mol File: 448949-22-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid(448949-22-2)
• EPA Substance Registry System: 4-({[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid(448949-22-2)

Safety Data

• Hazardous Substances Data: 448949-22-2(Hazardous Substances Data)

Upstream product

• 612088-38-7 pyrimidine-4,6-dicarboxylic acid monomethyl ester 
• 6345-43-3 pyrimidine-4,6-dicarboxylic acid dimethyl ester 

Downstream Products

• 690998-37-9 pyrimidine-4,6-dicarboxylic acid 4-(4-diethylcarbamoyl-benzylamide)-6-(3-methoxy-benzylamide) 

Relevant articles and documents

MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES

The present invention relates generally to bis-amide containing MMP inhibiting compounds, and more particularly to selectively deuterated bis-amide MMP-13 inhibiting compounds that exhibit increased stability or potency in relation to currently known MMP-

NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES

Pyrimidine-4,6-dicarboxamides of formula (I), are suitable for the selective inhibition of collagenase (MMP 13). The pyrimidine-4,6-dicarboxamides can thus be used for the treatment of degenerative joint diseases.