448949-22-2

Upstream product

• 612088-38-7 pyrimidine-4,6-dicarboxylic acid monomethyl ester 
• 6345-43-3 pyrimidine-4,6-dicarboxylic acid dimethyl ester 

Downstream Products

• 690998-37-9 pyrimidine-4,6-dicarboxylic acid 4-(4-diethylcarbamoyl-benzylamide)-6-(3-methoxy-benzylamide) 

Relevant academic research and scientific papers

MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES

The present invention relates generally to bis-amide containing MMP inhibiting compounds, and more particularly to selectively deuterated bis-amide MMP-13 inhibiting compounds that exhibit increased stability or potency in relation to currently known MMP-

Selective MMP-13 inhibitors

The invention relates to a pyrimidine-4,6-dicarboxylic acid diamide compound, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use. Particularly, the pyrimidine-4,6-dicarboxylic acid diamide compound is

NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES

Pyrimidine-4,6-dicarboxamides of formula (I), are suitable for the selective inhibition of collagenase (MMP 13). The pyrimidine-4,6-dicarboxamides can thus be used for the treatment of degenerative joint diseases.