448949-63-1

Upstream product

• 448949-65-3 (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid hydrogen chloride 
• 134984-63-7 (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester 
• 499137-88-1 (1S,3S,4R)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carbaldehyde 
• 542-92-7 cyclopenta-1,3-diene 
• 499137-90-5 {(1R,3S,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-3-yl}methanol 
• 188057-41-2 ethyl (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylate hydrochloride 

Relevant academic research and scientific papers

An improved synthesis of enantiopure 2-azabicyclo[2.2.1]heptane-3-carboxylic acid

A facile multigram scale preparation of (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid via stereoselective synthesis of the corresponding α-amino ester hydrochloride is detailed. Hitherto applied protocols for the synthesis of this cyclic proline

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

A short, convenient synthesis of enantiomerically pure N-protected 2-azanorbornane-3-carboxaldehydes and related amino alcohols

The aza-Diels-Alder reaction between cyclopentadiene and the bis(1-phenylethyl)imine of glyoxal provides a short route to the two enantiomerically pure exo-diastereomers of N-(1-phenylethyl)-2-azanorbornane-3-carboxaldehyde. Addition of 1-naphthylmagnesiu