448950-89-8

Basic information

• Product Name: 7-Chloro-1-methyl-5-phenyl-
• Synonyms: 7-Chloro-1-Methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-aMine;7-Chloro-1-methyl-5-phenyl-;Alprazolam EP Impurity G
• CAS NO: 448950-89-8
• Molecular Formula: C17H13ClN4
• Molecular Weight: 308.76492
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines
• Mol File: 448950-89-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 265-267°C
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
• PKA: 4.20±0.50(Predicted)
• CAS DataBase Reference: 7-Chloro-1-methyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-1-methyl-5-phenyl-(448950-89-8)
• EPA Substance Registry System: 7-Chloro-1-methyl-5-phenyl-(448950-89-8)

Safety Data

• Hazardous Substances Data: 448950-89-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay.

Upstream product

• 28981-97-7 alprazolam 
• 85966-74-1 ({2-[3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]-5-chlorophenyl}(phenyl)methanone) 

Relevant articles and documents

Identification of Alprazolam and its degradation products using LC-MS-MS

An efficient LC/MS/MS methodology for the analysis of Alprazolam API and Alprazolam tablets was developed. The analysis of the MS2 fragmentation profile, obtained from only one chromatographic assay, allows the identification of Alprazolam, its main degradation product, triazoaminoquinoleine (Imp G), the analysis of the MS3 spectra allows the identification of 5-chloro-[5-methyl-4H-1,2,4-triazol-4-yl]benzophenone (Imp C) and with SIM mode the 5-chloro-[2-(3-aminomethyl-5-methyl-1,2,4-triazol- 4-yl]benzophenone, opened-ring Alprazolam, proposed as precursor of triazoaminoquinoleine in basic and acid hydrolysis and only detected before by NMR analysis, was identified. With this method it is possible to study samples with only one chromatographic run, identifying unequivocally the impurities present, taking advantage of the MS-MS resource.