448959-76-0

Basic information

• Product Name: [2-(di-tert-butoxy-phosphoryloxy)-1-(4-octyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 448959-76-0
• Molecular Weight: 584.734
• Mol File: 448959-76-0.mol

Chemical Properties

• CAS DataBase Reference: [2-(di-tert-butoxy-phosphoryloxy)-1-(4-octyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(di-tert-butoxy-phosphoryloxy)-1-(4-octyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester(448959-76-0)
• EPA Substance Registry System: [2-(di-tert-butoxy-phosphoryloxy)-1-(4-octyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester(448959-76-0)

Safety Data

• Hazardous Substances Data: 448959-76-0(Hazardous Substances Data)

Upstream product

• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 16245-79-7 4-octylaniline 
• 448959-72-6 tert-butyl (R)-(3-hydroxy-1-((4-octylphenyl)amino)-1-oxopropan-2-yl)carbamate 
• 448959-68-0 [2-benzyloxy-1-(4-octyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 137348-86-8 di-tert-butyl diisopropylphosphoramide 

Relevant articles and documents

NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS

The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.

ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS

The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.

Synthesis of Para-alkyl aryl amide analogues of sphingosine-1-phosphate: Discovery of potent S1P receptor agonists

Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid with the capacity to induce a broad range of cellular responses via its interaction with the S1P family of G-protein coupled receptors. This report describes the synthesis of several