448963-99-3Relevant academic research and scientific papers
Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors
Letavic, Michael A.,Axt, Matt Z.,Barberia, John T.,Carty, Thomas J.,Danley, Dennis E.,Geoghegan, Kieran F.,Halim, Nadia S.,Hoth, Lise R.,Kamath, Ajith V.,Laird, Ellen R.,Lopresti-Morrow, Lori L.,McClure, Kim F.,Mitchell, Peter G.,Natarajan, Vijayalakshmi,Noe, Mark C.,Pandit, Jayvardhan,Reeves, Lisa,Schulte, Gayle K.,Snow, Sheri L.,Sweeney, Francis J.,Tan, Douglas H.,Yu, Chul H.
, p. 1387 - 1390 (2007/10/03)
A series of novel, selective TNF-α converting enzyme inhibitors based on 4-hydroxy and 5-hydroxy pipecolate hydroxamic acid scaffolds is described. The potency and selectivity of TACE inhibition is dramatically influenced by the nature of the sulfonamide
