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Usage

Uses

Used in Medical Procedures:
N,N-Diethyl-2-(methylamino)acetamide hydrochloride is used as a local anesthetic for medical procedures, particularly in dental work and minor surgeries. It functions by blocking the transmission of pain signals from nerve endings to the brain, providing temporary relief from discomfort.
Used in Pharmaceutical Synthesis:
As a precursor in the synthesis of other pharmaceuticals, N,N-Diethyl-2-(methylamino)acetamide hydrochloride plays a crucial role in the development of new medications, contributing to the advancement of the medical field.

InChI:InChI=1/C7H16N2O.ClH/c1-4-9(5-2)7(10)6-8-3;/h8H,4-6H2,1-3H3;1H

Downstream Products

• 1000926-20-4 N,N-diethyl-4-(2-hydroxybenzoyl)-1-methyl-1H-pyrrole-2-carboxamide 

Relevant academic research and scientific papers

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: Suppressing the rearrangement pathway in aqueous media

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O → N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid amide carriers were synthesized and evaluated as potential prodrugs displaying less ability to undergo rearrangement. These compounds were prepared in reasonable yield by a four-step synthetic method that uses the appropriate N-Boc-protected amino acid N-hydroxysuccinimide ester and secondary amine and chloromethyl chloroformate as key reactants. Their reactivity in pH 7.4 buffer and 80% human plasma at 37°C was assessed by RP-HPLC. The aminocarbonyloxymethyl esters containing a secondary carbamate group derived from amino acids such as glycine or phenylalanine were hydrolyzed quantitatively to the parent drug both in non-enzymatic and enzymatic conditions, with no rearrangement product being detected. The oral bioavailability in rats was determined for selected diclofenac derivatives. These derivatives displayed a bioavailability of 25 to 68% relative to that of diclofenac, probably due to their poor aqueous solubility and lipophilicity. These results suggest that further optimization of aminocarbonyloxymethyl esters as potential prodrugs for non-steroidal anti-inflammatory drugs require the use of amino acid carriers with ionizable groups to improve aqueous solubility.