44897-15-6

Basic information

• Product Name: N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE
• Synonyms: N,N-DIETHYL-2-METHYLAMINO-ACETAMIDE X HCL;Albb-006995;N~1~,N~1~-diethyl-N~2~-methylglycinamide(SALTDATA: FREE);N,N-diethyl-2-methylamino-ethanamide
• CAS NO: 44897-15-6
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.22
• Mol File: 44897-15-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 212.6°Cat760mmHg
• Flash Point: 82.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0152mmHg at 25°C
• CAS DataBase Reference: N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE(44897-15-6)
• EPA Substance Registry System: N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE(44897-15-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 44897-15-6(Hazardous Substances Data)

Usage

General Description

N,N-Diethyl-2-(methylamino)acetamide hydrochloride is a chemical compound that is commonly used as a local anesthetic and as a precursor in the synthesis of other pharmaceuticals. It is a white solid, soluble in water, and stable under normal conditions. N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE is commonly used in medical procedures as a local anesthetic, particularly for dental work and minor surgeries. It works by blocking the transmission of pain signals from the nerve endings to the brain, providing temporary relief from discomfort. N,N-Diethyl-2-(methylamino)acetamide hydrochloride is an important chemical in the medical field and is widely utilized for its anesthetic properties.

InChI:InChI=1/C7H16N2O.ClH/c1-4-9(5-2)7(10)6-8-3;/h8H,4-6H2,1-3H3;1H

Downstream Products

• 1000926-20-4 N,N-diethyl-4-(2-hydroxybenzoyl)-1-methyl-1H-pyrrole-2-carboxamide 

Relevant articles and documents

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: Suppressing the rearrangement pathway in aqueous media

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O → N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid amide carriers were synthesized and evaluated as potential prodrugs displaying less ability to undergo rearrangement. These compounds were prepared in reasonable yield by a four-step synthetic method that uses the appropriate N-Boc-protected amino acid N-hydroxysuccinimide ester and secondary amine and chloromethyl chloroformate as key reactants. Their reactivity in pH 7.4 buffer and 80% human plasma at 37°C was assessed by RP-HPLC. The aminocarbonyloxymethyl esters containing a secondary carbamate group derived from amino acids such as glycine or phenylalanine were hydrolyzed quantitatively to the parent drug both in non-enzymatic and enzymatic conditions, with no rearrangement product being detected. The oral bioavailability in rats was determined for selected diclofenac derivatives. These derivatives displayed a bioavailability of 25 to 68% relative to that of diclofenac, probably due to their poor aqueous solubility and lipophilicity. These results suggest that further optimization of aminocarbonyloxymethyl esters as potential prodrugs for non-steroidal anti-inflammatory drugs require the use of amino acid carriers with ionizable groups to improve aqueous solubility.