449171-44-2

Upstream product

• 449171-41-9 methyl (1S,2S,4R)-N-(tert-butoxycarbonyl)-2-hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylate 
• 449171-38-4 methyl (1S,2S,4R,2'R)-N-(tert-butoxycarbonyl)-2-[2'-methoxy-2'-(trifluoromethyl)phenylacetoxy]-7-azabicyclo[2.2.1]heptane-1-carboxylate 

Downstream Products

• 523988-37-6 (2S,5R)-1-azabicyclo[3.2.0]heptan-7-one-2-carboxylic acid methyl ester 
• 123409-85-8 (2R,5R)-1-azabicyclo[3.2.0]heptan-7-one-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of enantiopure analogues of 3-hydroxyproline and derivatives

All four enantiomerically pure 2-hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylic acids, novel restricted analogues of 3-hydroxyproline, are described. The synthesis starts with the Diels-Alder reaction between methyl 2-benzamidoacrylate and Danishefsky's