449177-38-2

Upstream product

• 108-24-7 acetic anhydride 
• 169048-88-8 ethyl 6-O-benzyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside 

Downstream Products

• 1064679-20-4 4-methoxyphenyl (3,4-di-O-acetyl-6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->3)-(4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzyl-β-D-glucopyranoside 
• 449177-47-3 3-O-benzyl-4,6-O-benzylidene-2-p-nitrobenzoyl-β-D-glucopyranosyl-(1->4)-6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->4)-6-O-p-methoxybenzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide 
• 449177-45-1 6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->4)-6-O-p-methoxybenzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide 
• 449177-43-9 acetic acid 3-acetoxy-6-[6-azido-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-hydroxy-2-(4-methoxy-benzyloxymethyl)-tetrahydro-pyran-3-yloxy]-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Synthesis of the trifucosylated N-linked hexasaccharide of a glycoprotein from Haemonchus contortus

The synthesis of a hexasaccharide from the inner part of an N-linked oligosaccharide portion of a glycoprotein from Haemonchus contortus is described. This hexasaccharide contains a novel fucosylation pattern with three α-linked fucosyl groups at 0-3, 0-6 and 0-3′ of the two N-acetylglucosamine residues. In the synthesis two consecutive regioselective glycosylations were performed, thereby limiting protecting group manipulations, to yield a trisaccharide with β-(1→4) linkages. Subsequent trifucosylation in one step, followed by inversion of configuration via a displacement reaction at C-2″ of the terminal glucosyl residue produced the resulting β-mannosyl linkage. The 2-acetamido-2-deoxy-glucosylamine residue was capped by an N-acetyl group and the hexasaccharide was deprotected. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.