4493-01-0

Upstream product

• 769-26-6 2-ethynyl-1,3,5-trimethylbenzene 
• 51118-05-9 1,5-dimesitylpenta-1,4-diyn-3-one 
• 1015423-95-6 1-hexylthio-2-(2,4,6-trimethylphenyl)ethyne 
• 77295-61-5 1,1-Dibrom-2-(2,4,6-trimethylphenyl)ethylen 
• 408511-61-5 2,4,6-trimethyl phenylpropiolic acid 

Downstream Products

• 39231-51-1 1,4-dimesityl-butane 
• 1262733-12-9 (Z,Z)-1,4-bis(2,4,6-trimethylphenyl)-1,4-bis(diphenylphosphanyl)-1,3-butadiene 
• 1629909-47-2 3,3’-bis(2,4,6-trimethylphenyl)-2,2’-binaphthyl 

Relevant academic research and scientific papers

Efficient and reusable CuI/1,10-phenanthroline-catalyzed oxidative decarboxylative homocoupling of arylpropiolic acids in aqueous DMF

An efficient method for synthesis of 1,3-diynes through the CuI/1,10-phenanthroline-catalyzed oxidative decarboxylative homocoupling of aryl pioprolic acids in aqueous DMF has been developed. The catalytic system was suitable for a variety of arylpropiolic acids, and the corresponding 1,3-diynes could be prepared in high yields. The catalytic system was recovered from the organic products by filtration and its aqueous DMF filtrate retained good activity even after at least four cycles of use.

Expedient synthesis of conjugated triynesviaalkyne metathesis

The first synthesis of conjugated triynes by molybdenum-catalysed alkyne metathesis is reported. Strategic to the success of this approach is the utilization of sterically-hindered diynes that allowed for the site-selective alkyne metathesis to produce th

Facile synthesis of 3, 3′-disubstituted 2, 2′-binaphthyls by transition-metal-catalyzed double benzannulation

3, 3′-Disubstituted 2, 2′-binaphthyls were prepared by the Cuor Re-catalyzed double benzannulation reaction of 2-(phenylethynyl) benzaldehyde with various butadiynes in the presence of trichloroacetic acid, in moderate to good yields. Acceleration of the second benzannulation was clearly observed.

Synthesis of 1,4-diarylsubstituted 1,3-diynes through ligand-free copper-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids

An efficient method of ligand-free Cu-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids was developed. When CuI was employed as the catalyst and I2 as the oxidant, the decarboxylative homocoupling reaction for Csp/s

Rh(I)-catalyzed decarbonylation of diynones via C-C activation: Orthogonal synthesis of conjugated diynes

Utilization of C-C bond activation as a unique mode of reactivity for constructing C-C bonds provides new strategies for preparing important organic molecules. Development of a Rh(I)-catalyzed C-C activation of diynones to synthesize symmetrical and unsymmetrical conjugated diynes through decarbonylation is reported. This C-C cleavage strategy takes advantage of the innate reactivity of conjugated ynones without relying on any ring strain or auxiliary directing group. This alkynation method also has orthogonal properties compared to typical cross-coupling reactions.

Two types of rhodium-catalyzed CS/CS metathesis reactions: formation of CS/CS bonds and CC/SS bonds

A rhodium complex catalyzes two types of single bond metathesis reactions of two CS bonds depending on the added ligand: CS/CS to CS/CS metathesis and CS/CS to CC/SS metathesis. In the presence of a catalytic amount of RhH(PPh3)4 and 1,1′-bis(diphenylphosphino)ferrocene (dppf), two 1-alkylthioalkynes exchange alkylthio groups to give equilibrium mixtures of four 1-alkylthioalkynes. When tris(p-methoxyphenyl)phosphine or diphenylmethylphosphine is used, 1,3-butadiynes are obtained.