449727-86-0

Upstream product

• 449727-85-9 acetic acid 2-bromo-4-methoxyphenyl ester 
• 158817-25-5 (R)-1-methoxy-4-((3-methylpent-4-ynyloxy)methyl)benzene 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 449727-90-6 trifluoromethanesulfonic acid 2-[(R)-3-(5-methoxybenzofuran-2-yl)butyl]-3-oxocyclohex-1-enyl ester 
• 449727-91-7 2-[(R)-3-(2,6-dimethoxycyclohexa-2,5-dienyl)-1-methylpropyl]-5-methoxybenzofuran 
• 796966-70-6 2-[(R)-3-(5-Methoxy-benzofuran-2-yl)-butyl]-cyclohexane-1,3-dione 
• 449727-87-1 acetic acid 2-[(R)-5-hydroxy-3-methylpent-1-ynyl]-4-methoxyphenyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B

The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.

Concise total synthesis of (-)-frondosin B using a novel palladium-catalyzed cyclization

Sidestepping stereochemical inversion: In an expedient, asymmetric total synthesis of (-)-frondosin B a novel palladium-catalyzed cyclization establishes the tetracyclic skeleton (see scheme). The absolute stereochemistry of naturally occurring marine met