449732-50-7Relevant academic research and scientific papers
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control
Aronov, Alex M.,Qing, Tang,Martinez-Botella, Gabriel,Bemis, Guy W.,Cao, Jingrong,Chen, Guanjing,Ewing, Nigel P.,Ford, Pamella J.,Germann, Ursula A.,Green, Jeremy,Hale, Michael R.,Jacobs, Marc,Janetka, James W.,Maltais, Francois,Markland, William,Namchuk, Mark N.,Nanthakumar, Suganthini,Poondru, Srinivasu,Straub, Judy,Ter Haar, Ernst,Xiaoling, Xie
experimental part, p. 6362 - 6368 (2010/03/31)
The Ras/Raf/MEK/ERK signal transduction, an oncogenic pathway implicated in a variety of human cancers, is a key target in anticancer drug design. A novel series of pyrimidylpyrrole ERK inhibitors has been identified. Discovery of a conformational change
