449753-14-4

Basic information

• Product Name: 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine
• CAS NO: 449753-14-4
• Molecular Weight: 820.923
• Mol File: 449753-14-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine(449753-14-4)
• EPA Substance Registry System: 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine(449753-14-4)

Safety Data

• Hazardous Substances Data: 449753-14-4(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 82921-54-8 N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide 

Downstream Products

• 82921-54-8 N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide 

Relevant articles and documents

Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides

An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.