449756-83-6

Basic information

• Product Name: Benzothiazole, 2-methyl-5-(oxiranylmethoxy)- (9CI)
• Synonyms: Benzothiazole, 2-methyl-5-(oxiranylmethoxy)- (9CI)
• CAS NO: 449756-83-6
• Molecular Formula: C₁₁H₁₁NO₂S
• Molecular Weight: 221.27554
• Product Categories: BENZOTHIAZOLE
• Mol File: 449756-83-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 2-methyl-5-(oxiranylmethoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-methyl-5-(oxiranylmethoxy)- (9CI)(449756-83-6)
• EPA Substance Registry System: Benzothiazole, 2-methyl-5-(oxiranylmethoxy)- (9CI)(449756-83-6)

Safety Data

• Hazardous Substances Data: 449756-83-6(Hazardous Substances Data)

Upstream product

• 68867-14-1 2-methyl-5-benzothiazolol 
• 67843-74-7 (S)-epichlorohydrin 
• 106-89-8 epichlorohydrin 

Downstream Products

• 753479-48-0 (2R)-3-((2S)-4-{[5-(2-fluorophenyl)isoxazol-3-yl]methyl}-2-methylpiperazinyl)-1-(2-methylbenzothiazol-5-yloxy)propan-2-ol 
• 601484-29-1 (2S)-3-((2S)-4-{[5-(2-fluorophenyl)isoxazol-3-yl]methyl}-2-methylpiperazinyl)-1-(2-methylbenzothiazol-5-yloxy)propan-2-ol 

Relevant articles and documents

Heteroaryl alkyl piperazine derivatives

Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of diabetes, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES

wherein: a.o. T is oxygen, sulfur, or NR11 , in which R11 is hydrogen or lower alkyl; V is -N1 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; X2 is optionally substituted aryl or optionally substituted heteroaryl; Y is optionally substituted dihydroheteroarcyl; and Z1 and Z2 are independently optionally substituted alkylene of 1-4 carbon atoms, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal’s (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

Substituted heterocyclic compounds

Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.