449804-31-3

Upstream product

• 202134-57-4 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 151-50-8 potassium cyanide 
• 2010-61-9 1,1,1,3,3,3-hexafluoro-2-(p-tolyl)propan-2-ol 

Downstream Products

• 876143-36-1 3-(4-hydroxy-phenyl)-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-propionitrile 
• 876143-41-8 3-furan-3-yl-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-propionitrile 
• 876143-28-1 3-oxo-3-pyridin-4-yl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-propionitrile 
• 876143-35-0 5-cyano-4-oxo-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-pentanoic acid 
• 876143-33-8 4-ethoxy-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-butyronitrile 
• 876143-38-3 6-hydroxy-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-hexanenitrile 
• 876143-39-4 4,4,4-trifluoro-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-butyronitrile 
• 876143-37-2 3-oxo-4-phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-butyronitrile 
• 876143-31-6 4-methyl-3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-pentanenitrile 
• 876143-30-5 3-oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-pentanenitrile 

Relevant academic research and scientific papers

Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors

We have previously reported the discovery of small molecule inhibitors of malonyl-CoA decarboxylase (MCD) as novel metabolic modulators, which inhibited fatty acid oxidation and consequently increased the glucose oxidation rates in the isolated working ra