44981-94-4

Basic information

• Product Name: N-(2-Cyanoethyl) GlycineEthyl Ester
• Synonyms: N-(2-Cyanoethyl) GlycineEthyl Ester;Glycine, N-(2-cyanoethyl)-, ethyl ester;ethyl 2-(2-cyanoethylaMino)acetate;N-Cyanoethylglycine ethyl ester;Ethyl N-(2-cyanoethyl)glycinate
• CAS NO: 44981-94-4
• Molecular Formula: C₇H₁₂N₂O₂
• Molecular Weight: 156.18238
• Mol File: 44981-94-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 272 °C at 760 mmHg
• Flash Point: 118.3 °C
• Appearance: /
• Density: 1.042 g/cm³
• Vapor Pressure: 0.00622mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: N-(2-Cyanoethyl) GlycineEthyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Cyanoethyl) GlycineEthyl Ester(44981-94-4)
• EPA Substance Registry System: N-(2-Cyanoethyl) GlycineEthyl Ester(44981-94-4)

Safety Data

• Hazardous Substances Data: 44981-94-4(Hazardous Substances Data)

Usage

General Description

N-(2-Cyanoethyl) GlycineEthyl Ester is a chemical compound that is commonly used as a reagent in organic synthesis. It belongs to the class of compounds known as ethyl esters and contains the functional groups of both nitrile and glycine. N-(2-Cyanoethyl) GlycineEthyl Ester is often utilized as an intermediate in the production of pharmaceuticals and agrochemicals, serving as a building block for the synthesis of more complex molecules. Its versatile reactivity and stability make it a valuable reagent in the field of organic chemistry, where it is frequently employed in the creation of various drugs and other biologically active compounds.

InChI:InChI=1/C7H12N2O2/c1-2-11-7(10)6-9-5-3-4-8/h9H,2-3,5-6H2,1H3

Upstream product

• 107-13-1 acrylonitrile 
• 459-73-4 GlyOEt*HCl 
• 623-33-6 glycine ethyl ester hydrochloride 
• 107-12-0 propiononitrile 
• 64-17-5 ethanol 
• 3088-42-4 N-(2-cyanoethyl)glycine 

Downstream Products

• 17775-54-1 N-Cyanethyl-glykokollhydrazid 
• 16172-31-9 N-benzyloxycarbonyl-N-(2-cyano-ethyl)-glycine ethyl ester 
• 266353-18-8 N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester 
• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 1276125-31-5 3-Amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester 
• 1276125-33-7 3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester 
• 1276125-30-4 3-cyano-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 1276125-32-6 C₁₆H₁₉N₅O₂ 
• 1276126-03-4 C₂₈H₄₄BrN₅O₂Si 
• 1276126-11-4 C₃₀H₄₂BrN₅O₂Si 
• 1276126-12-5 C₃₀H₄₁N₅O₂Si 
• 1276126-19-2 C₃₁H₄₄BrN₅O₂Si 
• 1276126-20-5 C₃₁H₄₃N₅O₂Si 
• 398491-59-3 3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 

Relevant articles and documents

Preparation method of zabofloxacin intermediate

The invention provides a preparation method of a zabofloxacin intermediate. The method comprises: reacting ethyl glycinate hydrochloride with acrylonitrile under catalysis of a base to form an intermediate I; then reacting the intermediate I with Boc anhydride under the function of a strong base to generate an intermediate III; reacting the intermediate III, the methoxyamine hydrochloride and formaldehyde to generate an intermediate IV; and then preparing the zabofloxacin intermediate by reacting the intermediate IV with methanesulfonyl chloride, performing reduction with sodium borohydride, and other steps. The zabofloxacin intermediate is prepared through nine steps with a high yield and high quality by the method, the material adding amount reaches the level of hundreds of grams, and the method is suitable for industrial production.

(R)- N - [5 - (2 - methoxy - 2 - phenyl-acetyl) - 1, 4, 5, 6 - tetrahydro-pyrrolo [3, 4 - c] pyrazole - 3 - yl] - 4 - (4 - methyl piperazine - 1 - yl) benzamide synthesis method

The invention belongs to the technical field of medicine and relates to a preparation method for PHA739358(Danusertib), i.e., (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide. According to the invention, altogether four reaction routes are designed, simple and easily available glycine is used as a raw material, reactions like addition, esterification, amino protection and cyclization are carried out so as to prepare (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide, yield of the route 1, 2 and 4 is more than 25%, respectively, and yield of the route 3 is more than 20%. The preparation method has the advantages of a few reaction steps, simple and convenient post-treatment operation, little time consumption, high yield and low total cost. Thus, a novel method is provided for preparation of the antitumor drug PHA739358.

AMINOPYRIMIDINES AS SYK INHIBITORS

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.