449811-63-6

Usage

Uses

Used in Pharmaceutical Industry:
(2,4-Difluorophenoxy)acetic Acid Methyl Ester is used as an intermediate in the synthesis of Pamapimod (P167500) for its role as a selective inhibitor of the α-isoform of p38 MAP kinase. This makes it a valuable compound in the development of targeted therapies for various diseases, including autoimmune and inflammatory conditions.

Upstream product

• 367-27-1 2,4-difluorophenol 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 449809-33-0 6-(2,4-difluorophenoxy)-2-(benzylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 864300-91-4 2-(2,4-difluorophenoxy)-3-hydroxy-3-[4-nitro-2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]propionic acid methyl ester 
• 449811-50-1 6-(2,4-difluorophenoxy)-8-ethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 449811-12-5 6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one 
• 1280218-27-0 6-(2,4-difluorophenoxy)-8-cyclopropyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 851885-71-7 6-(2,4-difluorophenoxy)-8-((S)-2-hydroxypropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 851885-66-0 6-(2,4-difluorophenoxy)-8-((R)-2-hydroxypropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 

Relevant academic research and scientific papers

Development of radioiodinated pyrimidinopyridone derivatives as targeted imaging probes of activated p38α for single photon emission computed tomography

Objective: p38α, a member of the mitogen-activated protein kinase superfamily, is ubiquitously expressed in a variety of mammalian cells. Activated p38α induces inflammatory responses to external stimuli, suggesting that non-invasive detection of activate