450356-77-1

Basic information

• Product Name: 4(1H)-Pteridinone, 6,7-bis(4-fluorophenyl)-
• CAS NO: 450356-77-1
• Molecular Formula: C18H10F2N4O
• Molecular Weight: 336.3
• Mol File: 450356-77-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pteridinone, 6,7-bis(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pteridinone, 6,7-bis(4-fluorophenyl)-(450356-77-1)
• EPA Substance Registry System: 4(1H)-Pteridinone, 6,7-bis(4-fluorophenyl)-(450356-77-1)

Safety Data

• Hazardous Substances Data: 450356-77-1(Hazardous Substances Data)

Upstream product

• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 
• 1672-50-0 4,5-diamino-6-hydroxypyrimidine 

Relevant articles and documents

Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase

From compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a pteridine hit compound with an IC50 of 15 μM. Our SAR studies were focused on the different groups at the 6- and 7-positions, substitutions at the 4-position, and replacement of N1 or N3 with carbon in the pteridine ring. We found that NH or OH at 4-position is critical for the inhibitory activity. Furthermore, a hydrophobic substituent at the 4-position may help compounds permeate through the cell membrane.