450841-56-2

Upstream product

• 450841-51-7 4-[(4-iodo-2-nitrobenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitrile 
• 371765-91-2 4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 375792-98-6 4-iodo-1-(bromomethyl)-2-nitrobenzene 
• 105-07-7 4-cyanobenzaldehyde 
• 41252-97-5 4-iodo-2-nitrotoluene 

Downstream Products

• 450841-59-5 thiophene-2-sulfonic acid {2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-yl)methoxymethyl]-5-iodophenyl}amide 
• 669009-73-8 naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide 
• 669009-75-0 4-[[2-(3,5-difluorobenzylamino)-4-iodobenzyloxy]-(3-methyl-3H-imidazol-4-yl)methyl]benzonitrile 
• 669009-76-1 N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-yl)methoxymethyl]-5-iodophenyl}benzamide 
• 669009-71-6 N-{2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.