451-85-4

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Dichloro-4-(trifluoromethoxy)benzene is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones. Its unique structure allows for versatile chemical reactions, facilitating the creation of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 1,3-Dichloro-4-(trifluoromethoxy)benzene is employed as an intermediate in the production of pesticides and other agricultural chemicals. Its role in these applications is crucial for enhancing crop protection and increasing agricultural productivity.
Used in Organic Synthesis:
1,3-Dichloro-4-(trifluoromethoxy)benzene is used as a solvent and a chemical intermediate in organic synthesis, enabling the formation of a wide range of organic compounds. Its properties make it suitable for use in various chemical reactions, broadening its applications in the field of organic chemistry.
Used in Chemical Intermediate Production:
1,3-DICHLORO-4-(TRIFLUOROMETHOXY)BENZENE is also utilized as a precursor in the synthesis of other chemical intermediates, playing a vital role in the production of a variety of chemical products. Its versatility and reactivity make it a valuable component in the chemical industry.

InChI:InChI=1S/C7H3Cl2F3O/c8-4-1-2-6(5(9)3-4)13-7(10,11)12/h1-3H

Upstream product

• 50353-36-1 2,4-dichloro-1-trichloromethoxy-benzene 
• 328-03-0 2-(2,4-dichlorophenoxy)-2,2-difluoroacetic acid 
• 889-02-1 ethyl 2-(2,4-dichlorophenoxy)-2,2-difluoroacetate 
• 541-73-1 1,3-Dichlorobenzene 

Downstream Products

• 672-09-3 3-nitro-4,6-dichloro-trifluoromethoxybenzene 
• 1548-17-0 2-Trifluormethoxy-5-methoxy-benzochinon 
• 1514-58-5 2,4-Dimethoxy-5-nitro-ω,ω,ω-trifluor-anisol 
• 1598-42-1 2,4-Dichlor-5-amino-ω,ω,ω-trifluor-anisol 
• 720-62-7 2.4-Dimethoxy-5-amino-ω.ω.ω-trifluor-anisol 
• 456-55-3 1-trifluoromethoxybenzene 

Relevant academic research and scientific papers

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

Catalytic C?H Trifluoromethoxylation of Arenes and Heteroarenes

The intermolecular C?H trifluoromethoxylation of arenes remains a long-standing and unsolved problem in organic synthesis. Herein, we report the first catalytic protocol employing a novel trifluoromethoxylating reagent and redox-active catalysts for the direct (hetero)aryl C?H trifluoromethoxylation. Our approach is operationally simple, proceeds at room temperature, uses easy-to-handle reagents, requires only 0.03 mol % of redox-active catalysts, does not need specialized reaction apparatus, and tolerates a wide variety of functional groups and complex structures such as sugars and natural product derivatives. Importantly, both ground-state and photoexcited redox-active catalysts are effective. Detailed computational and experimental studies suggest a unique reaction pathway where photoexcitation of the trifluoromethoxylating reagent releases the OCF3 radical that is trapped by (hetero)arenes. The resulting cyclohexadienyl radicals are oxidized by redox-active catalysts and deprotonated to form the desired products of trifluoromethoxylation.

Xenon Difluoride Mediated Fluorodecarboxylations for the Syntheses of Di- and Trifluoromethoxyarenes

XeF2 is demonstrated to be a more proficient fluorine-transfer reagent than either NFSI or Selectfluor in fluorodecarboxylations of both mono- and difluoroaryloxy acetic acid derivatives. This method efficiently converts a wide range of neutral and electron-poor substrates to afford the desired di- and trifluoromethyl aryl ethers in good to excellent yields. The purifications are facile, and the reaction times are less than 5 min, which makes these fluorodecarboxylations promising for future PET-imaging applications.

Preparation of aryl trifluoromethyl ethers

A one-step process for the synthesis of aryl trifluoromethyl ethers by reacting phenol or certain substituted phenols with a perhalomethane and hydrogen fluoride is provided. The compounds produced by the process of this invention are useful intermediates in the production of dyestuffs and pharmaceuticals.