45103-58-0Relevant academic research and scientific papers
Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506
Mabuchi, Miyuki,Shimizu, Tadashi,Ueda, Masahiro,Mitamura, Kuniko,Ikegawa, Shigeo,Tanaka, Akito
supporting information, p. 2788 - 2792 (2015/06/08)
Solid materials for affinity resins bearing long PEG spacers between a functional group used for immobilization of a bio-active compound and the solid surface were synthesized to capture not only small target proteins but also large and/or complex target proteins. Solid materials with PEG1000 or PEG2000 as spacers, which bear a benzenesulfonamide derivative, exhibited excellent selectivity between the specific binding protein carbonic anhydrase type II (CAII) and non-specific ones. These materials also exhibited efficacy in capturing a particular target at a maximal amount. Affinity resins using solid materials with PEG1000 or PEG2000 spacers, bear a FK506 derivative, successfully captured the whole target complex of specific binding proteins at the silver staining level, while all previously known affinity resins with solid materials failed to achieve this objective. These novel affinity resins captured other specific binding proteins such as dynamin and neurocalcin δ as well.
Composite electrolytes comprised of poly(ethylene oxide) and silica nanoparticles with grafted poly(ethylene oxide)-containing polymers
Jia, Zhe,Yuan, Wen,Zhao, Hui,Hu, Heyi,Baker, Gregory L.
, p. 41087 - 41098 (2015/02/19)
We designed, synthesized and characterized several novel hybrid inorganic/organic nanocomposite electrolytes that consist of poly(ethylene oxide) (PEO) based polymer grafted from silica nanoparticles. Poly(ethylene glycol)methyl ether methacrylate (PEGMA) was tailored on the silica surface through atom transfer radical polymerization (ATRP). A series of silica-polymers were synthesized with different lengths of PEO side chains. Electrolytes were prepared from the functionalized particles and low-molecular weight polyethylene glycol dimethyl ether (PEGDME) with the addition of LiI. Upon the introduction of particles, electrolytes became viscous and gel-like. With the increase of PEO side chains, the viscosity of the electrolytes increased dramatically, among which, silica-poly(PEGMA-1100) became solid-state. The room temperature conductivities of the hybrid silica-polymer electrolytes are in the range of 6 × 10-5to 1.2 × 10-4S cm-1. Silica-poly(PEGMA-475) and silica-poly(PEGMA-1100), with higher viscosity, exhibited better ionic conductivity. Surface-initiated copolymerization was also conducted to optimize the electrochemical performance of polymer coated silica nanoparticles. This journal is
Unique associative properties of copolymers of sodium acrylate and oligo(ethylene oxide) alkyl ether methacrylates in water
Tomatsu, Itsuro,Hashidzume, Akihito,Yusa, Shin-Ichi,Morishima, Yotaro
, p. 7837 - 7844 (2008/02/01)
A series of random copolymers of sodium acrylate and oligo(ethylene oxide) alkyl ether methacrylates (CnEmMA) with different lengths of ethylene oxide (EO) and alkyl groups were prepared by free-radical copolymerization at varying copolymer compositions. The lengths of the EO units (the number of EO units) (m) and the numbers of carbon atoms in the alkyl groups (n) ranged fro'm 0 to 8.7 and 1 to 6, respectively. The copolymers with n = 1 and m = 1-8.7 exhibited a marked increase in solution viscosity at polymer concentrations (Cp) higher than their overlap concentrations (C*) when the CnEmMA contents (x) in the copolymers were in a certain limited range. Namely, there was an optimum x value that yielded the highest viscosity as a consequence of the competition between inter- and intrapolymer associations; the maximum viscosities occurred around x ≈ 25, 15, 10, 7, and 3 mol % for m = 1, 2, 3, 4.2, and 8.7, respectively. The maximum viscosity decreased significantly as n was increased on going from 1 to 6, and for the copolymers with n = 6, no increase in the viscosity occurred, a trend opposite to what is expected to interpolymer hydrophobic associations. When Cp > C*, steady-shear viscosity depended on the nature of countercations; the viscosities were found to be higher in the order Li + > Na+ ? NH4+, whereas reduced viscosity in dilute regime (Cp C*) was independent of the species of the cations. Rheological properties were found to be typical of transient networks formed through very weak interpolymer associations. Thus, the large increase in solution viscosity was explained by simultaneous interactions of countercations with EO units via coordination and with the polyanion via counterion condensation.
