4511-76-6Relevant academic research and scientific papers
Sulfur-mediated synthesis of unsymmetrically substituted: N -aryl oxalamides by the cascade thioamidation/cyclocondensation and hydrolysis reaction
Ilment, Nikita V.,Lyssenko, Konstantin A.,Tikhonova, Tatyana A.,Volkova, Yulia A.,Zavarzin, Igor V.
, p. 5050 - 5060 (2020)
A facile and straightforward synthesis of unsymmetrically substituted N-aryl oxalamides from 2,2′-biphenyldiamines, 2-chloroacetic acid derivatives, elemental sulfur, and water has been developed. This protocol is distinguished by efficiency in water under metal-free conditions for N-aryl oxalamides bearing a side-chain NH2-group; it can be adapted for scale-up synthesis. The scope and limitations of this transformation have been investigated.
