4512-34-9

Upstream product

• 4512-42-9 N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanine 
• 83537-94-4 Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester 
• 154561-22-5 Z-Aib-OBt 
• 79775-03-4 2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionsaeure 
• 4576-16-3 2-(1'-((benzyloxycarbonyl)amino)-1'-methylethyl)-4,4-dimethyloxazolone 
• 83537-95-5 H-Aib-Aib-O(t-Bu) 
• 4512-38-3 Z-(Aib)4-OtBu 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 15030-72-5 Z-Aib-OH 

Relevant academic research and scientific papers

Oxazol-5(4H)-one from benzyloxycarbonyl-(Aib)4-OH

Benzyl N-[8-(4,4-dimethyl-5-oxo-4,5-dihydrooxazol-2-yl)-2,5,5,8- tetramethyl-3,6-dioxo-4,7-diazanon-2-yl]carbamate, C24H34N4O6, an oxazol-5(4H)-one from N-α-benzyloxycarbonyl-(Aib)4-OH (Aib = α-aminoisobutyryl) represents the longest peptide oxazolone so far characterized by X-ray diffraction. The overall geometry of the oxazolone ring compares well with literature data. The Aib(1) and Aib(2) residues are folded into a type III β-bend, while the conformation adopted by Aib(3), preceding the oxazolone moiety, is semi-extended. The disposition of the oxazolone ring relative to the preceding residue is stabilized by C-H···N and C-H···O intramolecular interactions.

Deracemization and the first CD spectrum of a 310-helical peptide made of achiral α-amino-isobutyric acid residues in a chiral membrane mimetic environment

Interaction of the racemic helical homo-octapeptide made by the achiral Cα-methyl alanine (Aib) amino acid with a chiral enantiopure micellar aggregate made of N-dodecylproline led to the deracemization of the helical Aib sequence thus allowing