451455-96-2

Upstream product

• 141776-91-2 1-bromomethyl-3,5-difluoro-benzene 
• 122-52-1 triethyl phosphite 

Downstream Products

• 848487-71-8 (E)-1-methoxymethyloxy-3-(3,5-difluoro)styrylbenzene 
• 848487-72-9 (E)-1-methoxymethyloxy-2-(3,5-difluoro)styrylbenzene 
• 848487-70-7 (E)-1-methoxymethyloxy-4-(3,5-difluoro)styrylbenzene 

Relevant academic research and scientific papers

Bismuth(III) Chloride Mediated Michaelis-Arbuzov Reaction: A Facile Synthesis of Substituted Arylphosphonates/Phosphinates and Bioactivity Evaluation

BiCl3 is economically affordable, less toxic and eco-friendly catalyst. A facile synthesis of substituted arylphosphonates/phosphinates in good yields was achieved using BiCl3 catalyzed via Michaelis-Arbuzov reaction. 5-Iodovanillin/

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential

Schizophrenia is a serious illness that affects millions of patients and has been associated with N-methyl-D-aspartate receptor (NMDAR) hypofunction. It has been demonstrated that activation of metabotropic glutamate receptor 5 (mGluR5) enhances NMDA receptor function, suggesting the potential utility of mGluR5 positive allosteric modulators (PAMs) in the treatment of schizophrenia. Herein we describe the optimization of an mGluR5 PAM by replacement of a phenyl with aliphatic heterocycles and carbocycles as a strategy to reduce bioactivation in a biaryl acetylene chemotype. Replacement with a difluorocyclobutane followed by further optimization culminated in the identification of compound 32, a low fold shift PAM with reduced bioactivation potential. Compound 32 demonstrated favorable brain uptake and robust efficacy in mouse novel object recognition (NOR) at low doses.

For organic electronic device, modified stable electrode having a work function and method

A device including an electrode, the electrode having a surface; a molecule bound to the surface of the electrode through a binding group; an organic electronic material in electrical contact with the electrode, wherein the molecule comprises at least one fluorinated aryl group, wherein the electrode contains a transparent conductive metal oxide, a carbon nanotube, or graphene.

Stable electrodes with modified work functions and methods for organic electronic devices

One embodiment is a method, comprising: depositing a molecule on an electrode, wherein the electrode has a surface and the molecule has a binding group (e.g., an anchoring group) that binds to the surface, thereby providing a work function that is stable for at least 100 hours under ambient conditions.

ELECTRONIC DEVICES COMPRISING NOVEL PHOSPHONIC ACID SURFACE MODIFIERS

In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R1 is a halogen, a alkyl group, a heteroalkyl group, an aryl group, or a heteroaryl group; R2 comprises from 3 to 30 CH2- groups, n = 0-5, m = 0-5, q = 1-3, and R2 comprises at least one ether linkage

Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes

The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI50) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the ability to induce apoptosis following drug treatment by the most potent agents in the series, e.g., 5dy and 5jy, an observation further reinforced by Annexin V-FITC analysis and fluorescence microscopy.