452056-86-9

Upstream product

• 5434-22-0 1,3,5-tris[3-(morpholin-4-yl)propyl][1,3,5]triazinane 
• 452056-82-5 N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide 
• 452056-79-0 N-{4-[2-cyano-2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 459-22-3 4-fluorophenylacetonitrile 
• 452056-81-4 N-{4-[2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 452056-80-3 1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 
• 54221-95-3 2-(acetylamino)isonicotinic acid 

Downstream Products

• 452056-91-6 N-{4-[3-(3-(morpholin-4-yl)propyl)-5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl]pyridin-2-yl}acetamide 

Relevant academic research and scientific papers

Imidazole compounds having an antiinflammatory effect

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the i

Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position

We prepared novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity by using our previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently