452056-90-5

Upstream product

• 452056-85-8 N-{4-[5-(4-fluorophenyl)-1-oxy-3-(2,2,6,6-tetramethylpiperidin-4-yl)-3H-imidazol-4-yl]pyridin-2-yl}acetamide 
• 80458-17-9 1,3,5-tris(2,2,6,6-tetramethylpiperidin-4-yl)-[1,3,5]-triazinane 
• 452056-82-5 N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide 
• 452056-81-4 N-{4-[2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 
• 452056-80-3 1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 459-22-3 4-fluorophenylacetonitrile 
• 452056-79-0 N-{4-[2-cyano-2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide 

Relevant academic research and scientific papers

Imidazole compounds having an antiinflammatory effect

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the i

2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS

The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the

Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position

We prepared novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity by using our previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub