452280-22-7

Upstream product

• 90050-59-2 5-bromo-2-methylbenzaldehyde 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 

Downstream Products

• 596094-67-6 C₈H₇BrClNO₂ 
• 1375103-00-6 3-(5-bromo-2-methoxyphenyl)-5-n-propylisoxazole 
• 1340277-93-1 (3-(5-bromo-2-methoxyphenyl)isoxazol-5-yl)methanol 
• 1375103-01-7 3-(5-allyl-2-methoxyphenyl)-5-propylisoxazole 
• 1375103-02-8 (3-(5-allyl-2-methoxyphenyl)isoxazol-5-yl)methanol 
• 1375102-93-4 4-allyl-2-(5-n-propylisoxazol-3-yl)phenol 
• 1375102-94-5 4-allyl-2-(5-(hydroxymethyl)isoxazol-3-yl)phenol 
• 1375102-95-6 4-bromo-2-(5-propylisoxazol-3-yl)phenol 

Relevant academic research and scientific papers

Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol

Novel isoxazole and pyrazole analogs based on natural biphenyl-neolignan honokiol were synthesized and evaluated for their inhibitory activities against nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells. The isoxazole skeleton

Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production

A series of novel 4-O-methylhonokiol analogs were synthesized in light of revealing structure-activity relationship for inhibitory effect of COX-2 enzyme. The key strategy of the molecular design was oriented towards modification of the potential metabolic soft spots (e.g., phenol and olefin) or by altering the polar surface area via incorporating heterocycles such as isoxazole and triazole. Most of all exhibited the inhibitory effects on COX-2 and PGF 1 production but not macrophage NO production. Especially, aryl carbamates 10 and 11 exhibited more potent inhibitory activity against COX-2 and PGF1 production.

An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes

An efficient protocol for the one-pot preparation of alkyl 3-aryl-5-methylisoxazole-4-carboxylates from aryl aldehydes is described. This method is readily amenable to the large scale preparation of isoxazoles as well as the parallel synthesis of isoxazole libraries.

Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

In an effort to identify orally bioavailable factor Xa inhibitors, two isoxazolines libraries were prepared to scan for novel P1 ligands. From this work, 4-chloro-3-aniline was identified as a novel and potent benzamidine mimic.