452295-54-4Relevant academic research and scientific papers
Resolution of 1-(2-naphthyl)ethanol by a combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction
Luo, Zhiyong,Swaleh, Sauda M.,Theil, Fritz,Curran, Dennis P.
, p. 2585 - 2587 (2002)
(Matrix presented) Kinetic resolution of a fluorous ester rac-1 with Candida antarctica B lipase provided a mixture of enantioenriched alcohol (R)-2 and fluorous ester (S)-1. The mixture was subjected to a fluorous triphasic reaction to give both enantiom
Separation of enantiomers by lipase-catalyzed fluorous-phase delabeling
Swaleh, Sauda M,Hungerhoff, Benno,Sonnenschein, Helmut,Theil, Fritz
, p. 4085 - 4089 (2007/10/03)
Simultaneous enantiomer-selective fluorous-phase delabeling and kinetic resolution was achieved by lipase-catalyzed alcoholysis of highly fluorinated esters of racemic alcohols. The separation of the fast-reacting delabeled enantiomers and the slow-reacting fluorous-phase labeled enantiomers was performed very efficiently by partition in an organic/fluorous biphasic solvent system.
