452305-67-8

Upstream product

• 452305-62-3 1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-hydroxy]ethylcarbamate 
• 849592-47-8 tert-butyl (S)-N-[1-(6-bromoindol-3-yl)-2-hydroxy]-ethylcarbamate 
• 452305-66-7 1,1-dimethylethyl (1S)-N-[1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-2-[(4-methylphenyl)sulfonyl]oxy]ethylcarbamate 

Downstream Products

• 849592-50-3 (S)-N-[2-{6-bromo-1-([4-methylphenyl]sulfonyl)indol-3-yl}-2-{(tert-butoxy)carbonylamino}ethyl]-2-(6-bromoindol-3-yl)-2-oxoethanamide 
• 452305-69-0 (S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-5,6-dihydro-1H-pyrazin-2-one 
• 452305-70-3 (3S,6S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-piperazin-2-one 
• 452305-71-4 (3R,6S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-piperazin-2-one 
• 452305-75-8 (6S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5,6-dihydro-1-methyl-1H-pyrazin-2-one 
• 452305-76-9 (3S,6S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1-methylpiperazin-2-one 
• 452305-77-0 (3R,6S)-3-(6-bromo-1H-indol-3-yl)-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1-methylpiperazin-2-one 
• 452305-68-9 (S)-6-bromo-N-[2-azido-1-[6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]ethyl]-α-oxoindole-3-acetamide 
• 452305-73-6 (6S)-3-[6-bromo-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5,6-dihydro-1H-pyrazin-2-one 
• 452305-74-7 (6S)-3-[6-bromo-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-6-[6-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5,6-dihydro-1-methyl-1H-pyrazin-2-one 

Relevant academic research and scientific papers

Total synthesis of marine bisindole alkaloids, (+)-hamacanthins A, B and (-)-antipode of 0cis-dihydrohamacanthin B

The total synthesis of the marine bisindole alkaloids, (+)-hamacanthins A (2a) and B (2b), and (-)-antipode of cis-dihydrohamacanthin B (2e) was achieved by transamidation-cyclization of N-(2-aminoethyl)-2-oxoethanamide 18 derived from (S)-indolylglycinol 10.

Asymmetric aminohydroxylation of vinyl indoles: A short enantioselective synthesis of the bisindole alkaloids dihydrohamacanthin A and dragmacidin A

A useful approach for the direct enantioselective synthesis of (S)-N-Boc-protected α-indol-3-ylglycinols from vinyl indoles using the Sharpless asymmetric aminohydroxylation reaction, with enantioselectivities of up to 94% and isolated yields of up to 65%