452309-51-2

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 81246-79-9 5'-dimethoxytrityluridine 
• 81246-81-3 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(tert-butyl)silyl]uridine 
• 58-96-8 uridine 
• 401916-25-4 carbonic acid 5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,5-dioxo-pyrrolidin-1-yl ester 

Downstream Products

• 452309-32-9 5'-O-(4,4'-dimethoxytrityl)-2'-O-[N-methyl-N-propargylaminocarbonyl]uridine 

Relevant academic research and scientific papers

Nucleoside compound, pharmaceutical composition and application thereof

The invention discloses a nucleoside compound, a pharmaceutical composition and application thereof. The nucleoside compound is a compound (I) with a structure shown as the following, or a pharmaceutically or physiologically acceptable salt thereof. The product of the invention has exact effect in the aspect of resisting virus, especially as a drug for resisting novel coronavirus or influenza virus.

Novel uridin-2′-yl carbamates: Synthesis, incorporation into oligodeoxyribonucleotides, and remarkable fluorescence properties of 2′-pyren-1-ylmethylcarbamate

A convenient method for the preparation of uridin-2′-yl carbamate derivatives is described. The stable 2′-O-(imidazol-1-ylcarbonyl)-3′,5′-O- (tetraisopropyldisiloxane-1,3-diyl)uridine, prepared from uridine, was treated with primary or secondary aliphatic

2′-O-Carbamate-containing oligonucleotides: Synthesis and properties

In order to evaluate the effect of a new 2′-carbohydrate modification on the hybridization properties of oligonucleotides, uridine 2′-O-carbamates were synthesized and incorporated into DNA strands. The key intermediate in the synthesis, a mixed succinimide carbonate 2, was treated with various amines to give 2′-O-carbamates 3. Thermal melting studies of modified oligonucleotides revealed that the presence of the 2′-O-carbamate modification significantly destabilized DNA/RNA duplexes. A molecular-modeling study indicated that unfavorable steric interactions between the hydrogen of the NH group from the carbamate substituent and the anomeric hydrogen of the sugar residue on the same strand of the duplex may be the contributing factor causing destabilization.