452336-90-2Relevant academic research and scientific papers
Asymmetric conjugate addition reactions of polymer-supported highly enantioenriched β-(trimethylsilyl)ethyl sulfoxides
Nakamura, Shuichi,Uchiyama, Youhei,Ishikawa, Satoshi,Fukinbara, Ryuta,Watanabe, Yoshihiko,Toru, Takeshi
, p. 2381 - 2383 (2002)
Optically active β-(trimethylsilyl)ethyl sulfoxides supported on Merrifield resin were treated with LDA and subsequently with methyl cinnamate at -78°C. Thermal treatment or reaction with TBAF liberated the optically active methyl 3-phenyl-5-trimethylsilylpent-4-enoate or methyl 3-phenylpent-4-enoate, respectively, in good yields with high enantioselectivity.
