4528-68-1

Usage

InChI:InChI=1/C18H18O/c19-17-11-13-18(14-12-17,15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10H,11-14H2

Upstream product

• 42420-85-9 4,4-diphenyl-cyclohexanol 
• 4528-64-7 4,4-diphenyl-2-cyclohexen-1-one 
• 61777-16-0 2-methylallyllithium 

Downstream Products

• 37416-21-0 2-(4,4-Diphenyl-cyclohex-1-enyl)-propionic acid ethyl ester 
• 118714-08-2 4,4-diphenylcyclohexanone tosylhydrazone 
• 87943-06-4 1-(4-Methoxy-phenylethynyl)-4,4-diphenyl-cyclohexanol 
• 35380-17-7 4,4-diphenylcyclohexanone oxime 
• 37416-31-2 2-(4,4-Diphenyl-cyclohex-1-enyl)-propionic acid 
• 95233-46-8 4,4-Diphenylcyclohexane-1-carboxylic Acid 
• 4528-64-7 4,4-diphenyl-2-cyclohexen-1-one 
• 87943-04-2 4,4-Diphenyl-1-prop-1-ynyl-cyclohexanol 
• 53969-22-5 4,4-Diphenyl-1,1-dimethoxycyclohexan 
• 1416325-39-7 C₅₉H₅₀O₅ 
• 1416325-38-6 C₄₂H₃₆O₃ 
• 1416325-37-5 C₄₉H₄₄O₄ 
• 50592-47-7 1-methyl-4,4-diphenylcyclohexanol 

Relevant academic research and scientific papers

Sulfonium ion-promoted traceless Schmidt reaction of alkyl azides

Schmidt reaction by sulfonium ions is described. General primary, secondary, and tertiary alkyl azides were converted to the corresponding carbonyl or imine compounds without any trace of the activators. This bond scission reaction through 1,2-migration of C-H and C-C bonds was accessible to the one-pot substitution reaction.

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

CHROMENE COMPOUND

A chromene compound having a short fading half period, especially, a short fading half period even at a low temperature in a general-purpose polymer solid matrix. The chromene compound is represented by the following formula (1). wherein R1 is a hydroxyl group or the like, R2 and R3 are each an aryl group or the like, C* is a spiro carbon atom, a spiro ring A represented by the following formula is a saturated hydrocarbon ring having 4 to 12 ring member carbon atoms or the like, and at least one ring member carbon atom constituting the ring A is a group represented by the following formula (4), and X is a divalent group such as arylene group, wherein R7 and R8 are each a cycloalkyl group or the like.

GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS

The invention relates to guanidine derivatives of formula (I) where: A = a chain of 3-c6 carbon atoms, one of which can be replaced by -N(R')- or -O- and R' = H or a substituent, where the ring skeleton only contains both double bonds of the thiazole component, the pharmaceutically-acceptable acid addition salts of basic compounds of formula (I), the pharmaceutically-acceptable salts of compounds of formula (I),, comprising acid groups, with bases, the pharmaceutically-acceptable esters of hydroxy or carboxyl group containing compounds of formula (I) and the solvates or hydrates thereof, which are partly known and partly novel and exhibit a neuropeptide FF receptor antagonist effect. The above are suitable for the treatment of pain and hyperalgesia, withdrawal symptoms in alcohol, psychotropic and nicotine dependencies, for improvement or cure of said dependencies, for regulation of insulin excretion, food intake, memory functions, blood pressure, electrolyte and energy management and for treatment of urinary incontinence. The above can be produced using generally used methods and processed to give medicaments.

New methodology for conjugate additions of allylic ligands to α,β-unsaturated ketones: Synthetic and spectroscopic studies

Michael additions of allylic ligands, including allyl, methallyl, crotyl, and prenyl systems, to a variety of α,β-unsaturated ketones can be effected in synthetically useful yields with allylcopper reagents in the presence of trimethylchlorosilane. Low-te

Reactions of 4,4-Diphenylcarbena-2,5-cyclohexadiene and Related Systems in Dimethyl Sulfoxide

Thermal decomposition of the lithium salt of the tosylhydrazone of 4,4-diphenyl-2,5-cyclohexadienone (10) in dimethyl sulfoxide produces 4,4-diphenyl-2,5-cyclohexadienone, p-benzylbiphenyl, 3,4-diphenyltoluene, 6,6-diphenyl-1-methylene-2,4-cyclohexadiene, and o-terphenyl, while similar treatment of the lithium salt of the tosylhydrazone of 4,4-diphenylcyclohexenone (26) generates 4,4-diphenylcyclohexenone, 5,5-diphenyl-1,3-cyclohexadiene, 4,4-diphenyl-1-methylene-2-cyclohexene, and 6,6-diphenyl-1-methylene-2-cyclohexene.Thermolysis of the lithium salt of the tosylhydrazone of 4,4-diphenylcyclohexanone (32) in dimethyl sulfoxide yields 4,4-diphenylcyclohexene, 4,4-diphenylcyclohexanone, and 4,4-diphenyl-1-methylcyclohexanol.The kinetics of the thermal decomposition of tosylhydrazone lithium salts 10, 26, and 32 in dimethyl sulfoxide in the temperature range 90-125 deg C were analyzed by evaluating the rate constants for the two consecutive first-order steps.The second step, for parent salts 10, 26, and 32, decomposition of diazo compound to carbene, exhibited values for k2 (110 deg C) of 8.22, 197, and 363 h-1, ΔG(activ)s of 27.2 +/- 3.1, 24.8 +/- 3.1, 24.2 +/- 0.9 kcal mol-1, and Δ(activ)s of -10.7 +/- 5.7, -6.3 +/- 5.8, and -8.1 +/- 1.7 eu.The activation parameters for decomposition of the diazo compounds are interpreted in terms of an increasing dipole moment in the transition state relative to ground state.Product formation from carbene intermediate is viewed in terms of a competition of a singlet oxygen abstraction reaction with intersystem crossing to triplet.