452905-58-7

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4,5,6-PENTAFLUOROPHENYL 1-ETHYLENESULFONATE is used as a synthetic intermediate for the development of pharmaceutical drugs. Its ability to introduce pentafluorophenyl and sulfonyl groups into various molecules makes it a key component in the synthesis of biologically active compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3,4,5,6-PENTAFLUOROPHENYL 1-ETHYLENESULFONATE is employed as a reagent in the synthesis of agrochemicals. Its versatility in chemical reactions allows for the creation of new molecules with pesticidal or herbicidal properties, contributing to the development of more effective and environmentally friendly agricultural products.
Used in Materials Science:
2,3,4,5,6-PENTAFLUOROPHENYL 1-ETHYLENESULFONATE is utilized as a building block in the synthesis of advanced materials. Its unique properties enable the development of materials with specific characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industrial applications.
Used in Organic Synthesis:
As a versatile reagent in organic synthesis, 2,3,4,5,6-PENTAFLUOROPHENYL 1-ETHYLENESULFONATE is used for the introduction of pentafluorophenyl and sulfonyl groups into organic molecules. This allows for the creation of new compounds with diverse applications in research and industry, including the development of new drugs, agrochemicals, and materials.

Upstream product

• 1622-32-8 2-Chloroethanesulfonyl chloride 
• 771-61-9 2,3,4,5,6-pentafluorophenol 

Downstream Products

• 452905-66-7 3-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-propane-1-sulfonic acid pentafluorophenyl ester 
• 452905-62-3 3-methyl-butane-1-sulfonic acid pentafluorophenyl ester 
• 41067-80-5 4-(vinylsulfonyl)morpholine 
• 1117975-56-0 4-ethyl-3-oxo-octane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-39-9 3-oxo-butane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-70-8 4,4-dimethyl-3-oxo-pentane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-44-6 3-oxo-hexane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-52-6 4-methyl-3-oxo-pentane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-48-0 5-methyl-3-oxo-hexane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-64-0 3-cyclohexyl-3-oxo-propane-1-sulfonic acid pentafluorophenyl ester 
• 1117975-60-6 3-cyclopropyl-3-oxo-propane-1-sulfonic acid pentafluorophenyl ester 
• 1206821-83-1 3-oxo-dodecane-1-sulfonic acid pentafluorophenyl ester 
• 1206821-82-0 3-oxo-octane-1-sulfonic acid pentafluorophenyl ester 
• 1226950-18-0 perfluorophenyl 3-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)propane-1-sulfonate 

Relevant academic research and scientific papers

Metal-free, hydroacylation of CC and NN bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof

In this report, a thorough evaluation of the use of aerobically initiated, metal-free hydroacylation of various CC and NN acceptor molecules with a wide range of aldehydes is presented. The aerobic-activation conditions that have been developed are in sharp contrast to previous conditions for hydroacylation, which tend to use transition metals, peroxides that require thermal or photochemical degradation, or N-heterocyclic carbenes. The mildness of the conditions enables a number of reactions involving sensitive reaction partners and, perhaps most significantly, allows for α-functionalised chiral aldehydes to undergo radical-based hydroacylation with complete retention of optical purity. We also demonstrate how the resulting hydroacylation products can be transformed into other useful intermediates, such as γ-keto- sulfonamides, sultams, sultones, cyclic N-sulfonyl imines and amides.

Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C-C bond formation has been developed. The reaction effectively enables the direct C-H activation of an aldehyde by mixing of an aldehyde

A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis

(Matrix presented) Various radical species generated from either the corresponding iodo-or bromo-compounds and tri-n-butyltin hydride were added in an intermolecular fashion to the activated acceptor pentafluorophenyl vinylsulfonate. The products of each