452929-51-0Relevant academic research and scientific papers
Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors
Leze, Marie-Pierre,Palusczak, Anja,Hartmann, Rolf W.,Le Borgne, Marc
experimental part, p. 4713 - 4715 (2009/04/08)
Two new series of benzonitrile derivatives on position 6 or 4 of indole ring were successfully synthesized via a Leimgruber-Batcho reaction. All the compounds were evaluated in vitro on the inhibition of aromatase (CYP19) and 17α-hydroxylase-C17,20-lyase
