452947-78-3Relevant academic research and scientific papers
Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer
Li, Huifang,Hassona, Mohamed D.H.,Lack, Nathan A.,Axerio-Cilies, Peter,Leblanc, Eric,Tavassoli, Peyman,Kanaan, Natalia,Frewin, Kate,Singh, Kriti,Adomat, Hans,Boehm, Konrad J.,Prinz, Helge,Guns, Emma Tomlinson,Rennie, Paul S.,Cherkasov, Artem
, p. 2425 - 2435 (2013/12/04)
The human androgen receptor plays a major role in the development and progression of prostate cancer and represents a well-established drug target. All clinically approved androgen receptor antagonists possess similar chemical structures and exhibit the s
A facile synthesis of homotriptycenes from anthranol derivatives
Cao, Derong,Gao, Chunmei,Meier, Herbert
, p. 3166 - 3168 (2007/10/03)
Substituted trans-10-benzyl-9-anthranols 5a,b and substituted 10, 10-dibenzyl-9-anthranol 8e undergo intramolecular cyclization in the presence of formic or oxalic acid to give homotriptycenes 9a,b,e. Depending on the amount of acid used, a competitive 1,
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Prinz, Helge,Ishii, Yukihito,Hirano, Takeo,Stoiber, Thomas,Camacho Gomez, Juan A.,Schmidt, Peter,Düssmann, Heiko,Burger, Angelika M.,Prehn, Jochen H. M.,Günther, Eckhard G.,Unger, Eberhard,Umezawa, Kazuo
, p. 3382 - 3394 (2007/10/03)
A novel series of 10-benzylidene-9(10H)-anthracenones and 10-(phenylmethyl)-9(10H)-anthracenones were synthesized and evaluated for antiproliferative activity in an assay based on K562 leukemia cells. The 3-hydroxy-4-methoxybenzylidene analogue 9h was fou
