452972-10-0 Usage
Uses
Used in Organic Synthesis:
4-Chloro-3-pyridylboronic acid is utilized as a reagent in cross-coupling reactions, which are pivotal for the formation of carbon-carbon and carbon-heteroatom bonds. This application is fundamental in the synthesis of complex organic molecules, including those found in pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4-CHLORO3-PYRIDYLBORONIC ACID is employed as a key intermediate in the synthesis of various drug molecules. Its ability to form stable intermediates and participate in multiple synthetic pathways makes it invaluable for the development of new medicinal compounds.
Used in Agrochemical Industry:
Similarly, in agrochemicals, 4-CHLORO3-PYRIDYLBORONIC ACID is used as a building block for the synthesis of active ingredients in pesticides and other crop protection products, contributing to the development of more effective and targeted agrochemicals.
Used in the Formation of Transition Metal Complexes:
4-CHLORO3-PYRIDYLBORONIC ACID also serves as a ligand in the creation of transition metal complexes, which have applications in catalysis, materials science, and as potential therapeutic agents. Its role in these complexes is to stabilize the metal center and modulate the reactivity and selectivity of the catalyst.
Used in Fine Chemicals Industry:
In the synthesis of fine chemicals, 4-CHLORO3-PYRIDYLBORONIC ACID is leveraged for its capacity to undergo a variety of synthetic transformations, enabling the production of high-value specialty chemicals used in fragrances, dyes, and other applications.
Check Digit Verification of cas no
The CAS Registry Mumber 452972-10-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,9,7 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 452972-10:
(8*4)+(7*5)+(6*2)+(5*9)+(4*7)+(3*2)+(2*1)+(1*0)=160
160 % 10 = 0
So 452972-10-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BClNO2/c7-5-1-2-8-3-4(5)6(9)10/h1-3,9-10H
452972-10-0Relevant articles and documents
Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters
Bouillon, Alexandre,Lancelot, Jean-Charles,Collot, Valerie,Bovy, Philippe R.,Rault, Sylvain
, p. 3323 - 3328 (2002)
This paper describes a general method for the synthesis and the isolation of novel 2,4, or 5-halopyridin-3-yl-boronic acids and esters 4, 7, 10, 13, 15. These compounds are prepared taking into account a regioselective halogen-metal exchange using nBuLi or a regioselective ortho-lithiation using lithium diisopropylamide and subsequent quenching with triisopropylborate starting from appropriate mono or dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pb-catalyzed coupling with a range of arylhalides and authorize a strategy to produce new pyridines libraries.
