452972-15-5

Basic information

• Product Name: 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98
• Synonyms: 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98;4-Chloropyridine-3-boronic acid, pinacol ester 98%;REF DUPL: 4-Chloropyridine-3-boronic acid pinacol ester;4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, HCl;4-Chloropyridine-3-boronic acid pinacol ester, HCl;4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(4-Chloropyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine hydrochloride, 2-(4-Chloropyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane hydrochloride;4-Chloropyridine-3-boronic acid, pinacol ester hydrochloride
• CAS NO: 452972-15-5
• Molecular Formula: C₁₁H₁₅BClNO₂
• Molecular Weight: 239.5085
• Product Categories: blocks;BoronicAcids;Pyridines;Organoborons;Pyridine;6
• Mol File: 452972-15-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 110
• Boiling Point: 326.774 °C at 760 mmHg
• Flash Point: 151.428 °C
• Appearance: /
• Density: 1.145 cm³
• Vapor Pressure: 0.000402mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep Cold
• PKA: 3.19±0.10(Predicted)
• CAS DataBase Reference: 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98(452972-15-5)
• EPA Substance Registry System: 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98(452972-15-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• TSCA: No
• HazardClass: IRRITANT
• Hazardous Substances Data: 452972-15-5(Hazardous Substances Data)

Usage

Uses

4-Chloropyridine-3-boronic acid pinacol ester, HCl

InChI:InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-7-14-6-5-9(8)13/h5-7H,1-4H3

Upstream product

• 626-61-9 4-Chloropyridine 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 557087-01-1 2-dimethylamino-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 36953-42-1 3-bromo-4-chloropyridine 

Downstream Products

• 1029806-35-6 5-[4-(4-chloropyridin-3-yl)benzyl]-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxylic acid tert-butyl ester 
• 1428879-95-1 7-(4-chloropyridin-3-yl)-3-(4-fluorophenyl)benzo[d]isoxazole 
• 1428880-32-3 7-(4-chloropyridin-3-yl)-3-(4-fluoro-2-methoxyphenyl)benzo[d]isoxazole 
• 1428880-26-5 7-(4-chloropyridin-3-yl)-3-(5-fluoro-2-methoxyphenyl)benzo[d]isoxazole 
• 1428879-91-7 7-(4-chloropyridin-3-yl)-3-phenylbenzo[d]isoxazole 
• 1035492-13-7 4-{2-amino-4-[3-(4-chloropyridin-3-yl)-4-fluorophenyl]-1-methyI-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate 
• 96630-88-5 4-chloro-3-hydroxypyridine 

Relevant articles and documents

A boron reagent dimethylamine base boric acidfrequency ester, synthesis and use

The invention relates to novel boronizing agent dimethylamino boronic acid pinacol ester PinB(DMA) the structure of which is in the specification. The specific synthesis steps are as follows: reacting raw material B(NME2)3 with pinacol for 2-5 hours under the solvent-free condition at the temperature of 50-70 DEG C; and distilling under the vacuum condition of minus 0.1 Mpa, and collecting fraction of 45-50 DEG C, namely the fraction is the product. The PinB(DMA) provided by the invention has the characteristics that water sensitivity is low, structure is stable, ultralow temperature reaction can be avoided when the PinB(DMA) participates in boronization reaction, and the like; and the market value of the PinB(DMA) is important. Compared with the similar processes, the synthesis process of the boronizing agent in the invention has the obvious characteristics of simple reaction steps, mild process condition, no solvent reaction, good process stability and simple post-treatment; and the boronizing agent prepared by the synthesis process is high in yield and good in purity. The boronizing agent is good in purity and has wide application prospect in the boronization reaction.