452979-80-5Relevant academic research and scientific papers
The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: The catalytic nucleophile
Stick, Robert V.,Watts, Andrew G.
, p. 541 - 554 (2002)
This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.
Synthesis of α-Deoxymono and Difluorohexopyranosyl 1-Phosphates and Kinetic Evaluation with Thymidylyl- and Guanidylyltransferases
Zhu, Jian-She,McCormick, Nicole E.,Timmons, Shannon C.,Jakeman, David L.
, p. 8816 - 8825 (2016/10/14)
Eight fluorinated isosteric α-d-glucopyranosyl 1-phosphate (Glc 1P) analogues have been synthesized. A promiscuity investigation of the thymidylyltransferase Cps2L and the guanidylyltansferase GDP-ManPP with these analogues showed that all were accepted b
