453509-75-6Relevant academic research and scientific papers
Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes
Banfi, Luca,Guanti, Giuseppe,Riva, Renata,Basso, Andrea,Calcagno, Emiliano
, p. 4067 - 4069 (2007/10/03)
Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection-transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.
