453562-69-1 Usage
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 453562-69-1 differently. You can refer to the following data:
1. Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
2. Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Check Digit Verification of cas no
The CAS Registry Mumber 453562-69-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,3,5,6 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 453562-69:
(8*4)+(7*5)+(6*3)+(5*5)+(4*6)+(3*2)+(2*6)+(1*9)=161
161 % 10 = 1
So 453562-69-1 is a valid CAS Registry Number.
InChI:InChI=1/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
453562-69-1Relevant articles and documents
SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
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, (2008/06/13)
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Substituted alkylamine derivatives and methods of use
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Page 126, (2010/02/05)
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
