453568-58-6

Upstream product

• 22037-28-1 3-bromofurane 
• 6952-59-6 3-cyanobromobenzene 

Downstream Products

• 453568-55-3 3-(2-pyridyl)-2-(3-cyanophenyl)-furan 
• 856570-76-8 3-(5-fluoro-2-pyridyl)-2-(3-cyanophenyl)-furan 
• 856570-77-9 3-(5-chloro-2-pyridyl)-2-(3-cyanophenyl)-furan 

Relevant academic research and scientific papers

Reactivity of 3-Bromofuran in Pd-Catalyzed C-H Bond Arylation toward the Synthesis of 2,3,5-Triarylfurans

Arylation of the C-H bond at the C2 position of 3-bromofuran is achieved using aryl bromides as coupling partners in the presence of phosphine-free Pd(OAc) 2 /KOAc in DMA. This procedure gives C2,C5-di- and even C2,C4,C5-triarylated 3-bromofuran derivatives when larger amounts of aryl bromides are employed. In addition, C2,C3,C5-triarylated furans-containing three different aryl groups-are synthesized via a C2-H bond arylation/Suzuki reaction/C5-H bond arylation sequence.

Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.